ISM1 and colorectal carcinoma: Additionally, genes that were highly correlated with ISM1 (cor > 0.7) but not members of the EMT pathway, such as ITGBL1 (Matsuyama et al., 2019), NRP-2 (Liu et al., 2019; Zhang et al., 2019), NOX4 (Shen et al., 2020), and GLI3 (Shen et al., 2021), have already been demonstrated to promote EMT, cell invasion and migration in CRC.