ISM1 and neoplasm: In TCGA cohort, after comparing the expression of ISM1 among cases with different clinicopathological characteristics, we found that expression was higher in patients with age < 60 (P < 0.05), a larger tumor size (P < 0.05), lymph node involvement (P < 0.001), and advanced stages (P < 0.01) (Figures 2A–D).