Additionally, genes that were highly correlated with ISM1 (cor > 0.7) but not members of the EMT pathway, such as ITGBL1 (Matsuyama et al., 2019), NRP-2 (Liu et al., 2019; Zhang et al., 2019), NOX4 (Shen et al., 2020), and GLI3 (Shen et al., 2021), have already been demonstrated to promote EMT, cell invasion and migration in CRC. The gene discussed is NOX4; the disease is colorectal carcinoma.