Zhu et al. (2020) found a new type of oncogenic lncRNA RP11-757G1.5 through microarray analysis, which is overexpressed in CRC tissues, especially in aggressive cases. In addition, the upregulation of RP11-757G1.5 is closely related to the adverse clinical outcome of CRC patients. Further functional analysis showed that RP11-757G1.5 can promote cell proliferation in vitro and in vivo. The mechanism for this phenomenon is that RP11-757G1.5 regulates the expression of YAP1 and promotes the development of CRC by competitively binding miR-139-5p to inhibit its activity (Zhu et al., 2020). Here, YAP1 is linked to colorectal carcinoma.