Alb-to-Fib ratio (AFR), which combines Alb and Fib, has been used as prognostic factors for different classes of diseases, including peritonitis-induced sepsis (13), advanced epithelial ovarian cancer (14), untreated chronic lymphocytic leukemia (15), and nonsmall cell lung cancer (16). The gene discussed is FBL; the disease is B-cell chronic lymphocytic leukemia.