C5a peptidase, a well-studied endopeptidase in GAS and one of the proteins identified in the proteomic profile of EVs from the SSI-1 strain (Supplementary Table 2), is capable of degrading and functionally inactivating IL-8, thereby contributing to the establishment of local infections (Cleary et al., 1992; Edwards et al., 2005; Zinkernagel et al., 2008). Here, SOCS1 is linked to infection.