KEGG terms of the computed 1,479 target genes allowed us to pin-point and identify target genes of PGRMC1 altered miRNAs that are uniquely involved within the top signaling pathways, which interestingly included, p53 signaling pathway, cell cycle and pathways in cancers (Figure 2C; Supplementary Figure 1 and Supplementary Table 7). This evidence concerns the gene TP53 and cancer.