SF3B1 and uveal melanoma: Despite their notable absence in CM, alterations in the SF3B1 gene are not unique to MM - similar mutations have also been detected in uveal melanoma, breast cancer, myelodysplastic syndromes, and chronic lymphocytic leukemia, including mutation hotspots such as codon 700, 622, 625, 662, and 666 (99, 113).