To be more specific, SF3B1 mutations at codon 625 are predominately associated with mucosal and uveal melanoma, while alterations at codon 700 are present across myeloid leukemia and chronic lymphocytic leukemia (6), implying disparate SF3B1 mutational preference that is possibly related to distinct etiology. This evidence concerns the gene SF3B1 and B-cell chronic lymphocytic leukemia.