Ipilimumab against cytotoxic T-lymphocyte antigen 4 (CTLA4), nivolumab and pembrolizumab against programmed death 1 (PD1) as well as atezolizumab against programmed death-ligand 1 (PD-L1) are approved by the FDA for the treatment for advanced melanoma either as monotherapy or combination therapy (166). The gene discussed is CTLA4; the disease is melanoma.