When exposed the CM to human umbilical vascular endothelial cells (HUVEC) cells, CM from PCDHB17P overexpression breast cancer cells promoted the tube formation ability, whereas the angiogenesis was inhibited by the CM from PCDHB17P-silenced breast cancer cells (Figures 3C, D, Supplementary Figure 2C). The gene discussed is PCDHB17P; the disease is breast carcinoma.