HMGB1 and peripheral nerve injury: In another rodent study, peripheral nerve injury [tibial nerve injury (TNI)] resulted in the redistribution of HMGB1 from the nucleus to the cytoplasm in sensory neurons.36 Systemic injection of GLA 1 reversed TNI-induced mechanical hyperalgesia at 14 days and 3 months following nerve injury, presumably through HMGB1 inhibition.