Pharmacological inhibition of 11β-HSD type 2 (11β-HSD2) has been shown to decrease COX-2 expression and activity in colonic adenomas and tumours and significantly suppress adenoma and tumour growth, by increasing tumour glucocorticoid activity, which in turn selectively blocks local COX-2 activity.24 Glycyrrhizin 1 is an 11β-HSD2 inhibitor that has been shown to suppress adenoma COX-2 expression.24 This evidence concerns the gene PTGS2 and neoplasm.