Hence, we speculated that quercetin (MOL000098), kaempferol (MOL000422), isorhamnetin (MOL000354), and formononetin (MOL000392) regulate the PI3K-Akt signaling pathway, viral carcinogenesis, microRNAs in cancer, cell cycle, and MAPK signaling pathway, and so on, via core target genes MAPK1 (PDB ID: 4iz5), AKT1 (PDB ID: 1unq), GSK3B (PDB ID: 4afj), CDKN1A (PDB ID: 2zvw), TP53 (PDB ID: 2k8f), RELA (PDB ID: 1nfi), MYC (PDB ID: 5g1x), GRB2 (PDB ID: 1gri), JUN (PDB ID: 1s9k), and EGFR (PDB ID: 5wb7). The gene discussed is MAPK1; the disease is cancer.