TIMP1 and Bloom syndrome: Regarding the BLM-induced PF model, research has confirmed that DBT inhibits oxidative stress by suppressing protein kinase D1 (PKD1)/NF-κB/manganese superoxide dismutase (MnSOD) signaling pathway [18], restraining the synthesis of ECM, and balancing the metalloproteinase (MMP)/tissue inhibitor of metalloproteinase 1 (TIMP-1) system [64].