Further studies by De Boeck and colleagues found that BM-MSCs stimulate the invasion, survival, and tumorigenesis of CRC cells by releasing soluble NRG1 and activating HER2/HER3-dependent PI3K/Akt signaling cascade in CRC cells, and the high expression of NRG1 is associated with poor prognosis [149]. Here, AKT1 is linked to colorectal carcinoma.