Naito and colleagues confirmed that MSCs induce the tumor-stromal formation and EMT process by expressing secreted protein acidic and rich in cysteine (SPARC) [151] and demonstrating a stronger ability to attack peripheral tissues through the mediation of newly expressed surface TGF-β on MSCs after coculture with tumor cells [152], thereby promoting the occurrence and development of CRC. Here, SPARC is linked to neoplasm.