In addition to MSCs promoting the EMT process of CRC through direct cell-to-cell contact [156], recent studies by Li and colleagues found that miR-222 carried by extracellular vesicles derived from MSCs targets ATF3 binding and suppresses the transcriptional activity of AKT1, thereby promoting malignant invasion and immune escape of CRC cells [157]. This evidence concerns the gene AKT1 and colorectal carcinoma.