FCGR3A and Crohn disease: Gene FCGR3A—upregulated in three of the CVD tissues (Brain – Spinal cord adj.P.val = 0.02; Brain – Caudate adj.P.val = 0.03; Artery – Tibial adj.P.val = 0.02)—encodes a receptor that binds the Fc portion of IgG, and it affects the pharmacokinetics in patients with Crohn’s Disease (Termant et al., 2015).