A report by Fu et al. (2015) indicated ENO1 was overexpressed in non-small cell lung cancer, promoting cell glycolysis, proliferation, migration, invasion, and tumorigenesis by activating the FAK-mediated PI3K/Akt pathway and further modulating their downstream signal molecules (Song et al., 2014). This evidence concerns the gene ENO1 and non-small cell lung carcinoma.