SH2B3 and acquired polycythemia vera: The majority of the SH2B3 variants found in patients with PV and also in patients with p.Val617Phe-negative erythrocytosis were located in the PH domain, with the amino acid residue 208 (exon 2) as a preferential mutational target site (Spolverini et al., 2013; McMullin and Cario, 2016; Maslah et al., 2017).