Moreover, the increased/decreased numbers of ZBTB16-expressing CD8+ T cells in patients with metastatic melanoma/autoimmune disease, respectively, suggest that these cells, akin to their murine CD8α+CD8β-TCRαβ+ counterparts, may be capable of suppressing the inflammatory responses in vivo (47, 58). The gene discussed is CD8A; the disease is metastatic melanoma.