ZBTB1 seems to specifically regulate asparagine synthesis in many T-lineage ALL (T-ALL) cell lines (like CUTTL-1, Jurkat & SUPT-1) by directly promoting the transcription of ASNS (asparagine synthetase), and thus may represent a potential target in the treatment of patients with T-ALL (191). Here, ZBTB1 is linked to acute lymphoblastic leukemia.