Since the discovery of chromosomal translocations of ZBTB16 in human acute promyelocytic leukemia and BCL6 in B-cell lymphomas in the 1990s, numerous studies have been performed to investigate roles of ZBTB proteins in the development, function and neoplastic transformation of hematopoietic cells (21, 26, 184). Here, BCL6 is linked to B-cell non-Hodgkin lymphoma.