By contrast, mice with an inducible deletion of ZBTB7A (LRF, leukemia/lymphoma-related factor) exhibit a grossly normal thymic T-cell development, but an aberrantly increased number of extrathymic DP T cells in the bone marrow (BM) that is reversed by blocking NOTCH signaling (Figure 1A) (85, 86). Here, ZBTB7A is linked to leukemia.