ZBTB1 seems to specifically regulate asparagine synthesis in many T-lineage ALL (T-ALL) cell lines (like CUTTL-1, Jurkat & SUPT-1) by directly promoting the transcription of ASNS (asparagine synthetase), and thus may represent a potential target in the treatment of patients with T-ALL (191). The gene discussed is ASNS; the disease is acute lymphoblastic leukemia.