They interact with lymphocytes, macrophages, as well as other immune cells in the synovium by generating pro-inflammatory cytokines, chemokines along with tissue-destructive factors consisting of IL-6, IL-8 and MMPs (27, 37–39) and play an imperative role in the continuous inflammation and bone destruction of RA synovium (40, 41). This evidence concerns the gene IL6 and rheumatoid arthritis.