Out of the 594 genes, eight genes were not detected; 53 were significantly modulated in SS KCS patients: 4 genes were downregulated (TRAF5, TGFBI, KLRAP1, and CMKLRI), and 49 genes were upregulated using a stringent 1.5-fold increase or decrease threshold (volcano plot in Figure 1A). This evidence concerns the gene TRAF5 and dry eye syndrome.