CD276 and melanoma: found that the knockdown of B7-H3 increased the in vitro and vivo sensitivity of melanoma cells to the chemotherapeutic agents dacarbazine and cisplatin in parallel with a reduction in p38 MAPK phosphorylation; they also observed the increased expression of dual-specific MAP kinase phosphatase (MKP) DUSP10 (a MKP known to dephosphorylate and inactivate p38 MAPK) in B7-H3 knockdown cells, indicating that B7-H3-mediated chemoresistance in melanoma cells is driven through a mechanism involving the DUSP10-mediated inactivation of p38 MAPK (60) (Figure 3).