TLR4 and exocrine pancreatic carcinoma: proved that sB7-H3 first upregulated TLR4 expression, then activated NF-κB signaling, and finally promoted IL-8 and VEGF expression and demonstrated for the first time that sB7-H3 promoted the invasion and metastasis of pancreatic carcinoma cells through the TLR4/NF-κB pathway (58) (Figure 3).