VDAC1 and infection: Iyer et al. (2018) showed that durlobactam enters A. baumannii cells through OmpA, the major and most abundant porin. Virulence of an A. baumannii strain in a mouse infection model was greatly impaired when OmpA was deleted, suggesting that loss of the porin is an unlikely mechanism for developing resistance to durlobactam (Iyer et al., 2018).