In terms of FGF21 regulating miRNAs, Li et al. reported that FGF21 improves ischemic arrhythmias via inhibiting miRNA-143/early growth response protein 1 pathway in a myocardial infarction model (53), yet, the effect of FGF21/miRNA-143 in regulating DCM needs further investigation. Here, FGF21 is linked to myocardial infarction.