FGF21 and atherosclerosis: Given that FGFR1 is highly-expressed in aorta (66), Wei et al. further found that the inhibiting effect of FGF21 on Syk and NLRP3 inflammasome activity is abolished by FGFR1 inhibitor in vascular smooth muscle cells (VSMCs) (13), which indicates that FGF21 may directly act on VSMCs to improve atherosclerosis.