As we have known that the upregulation of miRNA-34a in obesity restrains fat browning partly by the suppression of FGF21 signaling and SIRT1, while down-regulation of miRNA-34a could upregulate the expression of FGFR1, β-klotho and SIRT1 function to reduce adiposity (51), thus it is convincible that miRNA-34a inhibition may attenuate diabetic vascular complications by improving hepatic FGF21 signaling. This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.