Besides, a previous study demonstrated that FGF21 also exerts lipid-lowering and anti-oxidative effect through activating AMPK/acetyl-CoA carboxylase (ACC)/carnitine palmitoyltransferase-1 (CPT-1) pathway and AMPK/protein kinase B (Akt2)/glycogen synthase kinase-3β (GSK3β)/Fyn/nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway in a mice model of type 2 DM (T2DM) (21). This evidence concerns the gene NFE2L2 and type 2 diabetes mellitus.