Interestingly, pyroptosis, an inflammasome-associated regulatory necrosis, is closely associated with the pathogenesis of neurodegenerative diseases (Wang et al., 2019; Huang et al., 2021) and METH induces ER stress that mediates GSDME-dependent pyroptosis in hippocampal neuronal cells (Liu et al., 2020). This evidence concerns the gene GSDME and neurodegenerative disease.