The top 10 pathways included neuroactive ligand-receptor interaction, proteasome, calcium signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Epstein-Barr virus infection, Changas disease, human cytomegalovirus infection, Parkinson’s disease, Kaposi sarcoma-associated herpesvirus infection and endocrine resistance. The gene discussed is RENBP; the disease is Parkinson disease.