A-1210477 as a monotherapy or in a combination with Navitoclax resulted in death of different cell lines including MM, melanoma, and non-small cell lung cancer cell lines that were found to be Mcl-1 dependent by BH3 profiling or siRNA rescue experiments (Leverson and et al., 2015; Mukherjee and et al., 2018). This evidence concerns the gene MCL1 and Miyoshi myopathy.