The anti-apoptotic protein Mcl-1 is critical in survival and drug resistance of several malignancies including MM (Krajewska et al., 1996; Miyamoto et al., 1999; Andersen et al., 2005; Song et al., 2005; Ding et al., 2007; Boisvert-Adamo et al., 2009; Brotin et al., 2010). Here, MCL1 is linked to Miyoshi myopathy.