MCL1 and neoplasm: The in vitro and in vivo preclinical studies demonstrated that UMI-77 potently inhibits tumor growth and induces apoptosis in MM cells (Azmi and et al., 2013), and pancreatic cancer cells lines (Abulwerdi et al., 2014), both of which rely on the Mcl-1 protein as a survival factor (Miyamoto et al., 1999; Schniewind et al., 2004; Ren et al., 2009).