Some data showed that IL-1β, IL-2, IL-6, TNF-α, INF-γ, and other inflammatory factors in peripheral blood of patients with VD increased in varying degrees (Guoping et al., 2015; Schmitz et al., 2015), while IL-4 and IL-10 decreased in varying degrees (De Luigi et al., 2002; Liu et al., 2018). Here, TNF is linked to sexually transmitted disease.