Knockdown of SMN-AS1 with antisense oligonucleotides (ASOs) can dissociate PRC2 from the SMN promoter and increase SMN expression in both in vitro and in vivo SMA models (d’Ydewalle et al., 2017; Woo et al., 2017). This evidence concerns the gene SMN1 and proximal spinal muscular atrophy.