Two independent studies identified SMN-AS1 as an antisense lncRNA that arises from the SMN locus and recruits the PRC2 complex to transcriptionally repress SMN expression and to have relevant implications for Spinal Muscular Atrophy (SMA) (d’Ydewalle et al., 2017; Woo et al., 2017). Here, SMN2 is linked to spinal muscular atrophy.