LRP1 and Alzheimer disease: Lrp1-AS directly binds to HMGB2, a non-histone chromatin modifier, inhibiting its ability to promote SREBP1A-dependent transcription of Lrp1. Accordingly, increased levels of LRP1-AS and a reduction in LRP1 expression in human AD brain samples compared to age-matched controls were observed (Yamanaka et al., 2015).