Two independent studies identified SMN-AS1 as an antisense lncRNA that arises from the SMN locus and recruits the PRC2 complex to transcriptionally repress SMN expression and to have relevant implications for Spinal Muscular Atrophy (SMA) (d’Ydewalle et al., 2017; Woo et al., 2017). The gene discussed is SMN1; the disease is spinal muscular atrophy.