In AD, the lncRNAs 51A/SORL1-AS and 17A have both been suggested to interfere with the alternative splicing of their neighboring genes - SORL1 encoding Sortilin-1 and GPR51 encoding GABA receptor B2, respectively - and their expression is upregulated in the brain tissue from AD patients (Massone et al., 2011; Ciarlo et al., 2013). Here, SORT1 is linked to Alzheimer disease.