The beneficial effects of omega-3 PUFAs on human health require adequate doses and duration, as a low dose of omega-3 PUFAs (180 mg of EPA and 120 mg of DHA) for 8 weeks does not have significant effects on inflammatory and oxidative stress markers in people with type 2 diabetes (7), while a higher dose of omega-3 PUFAs (1,200 mg DHA + EPA) for 12 weeks could improve insulin sensitivity and reduce the triglyceride levels in individuals with a high risk of type 2 diabetes (8). This evidence concerns the gene INS and type 2 diabetes mellitus.