A study on mice with dystrophin protein deficiency who received 10 mg/kg of rosuvastatin, showed significantly increased areas of myonecrosis and inflammation, while mice without altered dystrophin who received the same doses showed increased levels of NF-Κβ, TNF-α as well as increased creatine kinase activity31, which suggests that high doses of rosuvastatin could potentiate the expression of some genes that encode proteins of inflammation pathways. This evidence concerns the gene DMD and gas gangrene.