TNF and protein S deficiency: A study on mice with dystrophin protein deficiency who received 10 mg/kg of rosuvastatin, showed significantly increased areas of myonecrosis and inflammation, while mice without altered dystrophin who received the same doses showed increased levels of NF-Κβ, TNF-α as well as increased creatine kinase activity31, which suggests that high doses of rosuvastatin could potentiate the expression of some genes that encode proteins of inflammation pathways.