HIF1A and flatulence: At that time point GAS skin lesions from HIF-1α KO mice presented with reduced percentages and absolute numbers of NKp46+ NK cells (Fig. 5a and Supplementary Fig. 9a) of which the vast majority (≈85−90%) were NK cells and only a minor fraction intILC1s (≈7−4%) and ILC1s (≈4–3%) (Supplementary Fig. 9b, c).