HIF1A and neoplasm: This is in line with our previous report on tumour-infiltrating NKp46+ cells where HIF-1α-deficiency leads to a lower number of tumour-infiltrating NK cells with reduced effector function as well as lower levels of NK cell-derived antiangiogenic sFlt1, increased VEGF bioavailability and excessive angiogenic signalling in the tumour microenvironment17.