MAPK8 and neoplasm: Over the past decades, great progress has been made in exploring the mechanisms of tumor progression, in which numerous oncogenes, tumor suppressor genes, and multiple signaling pathways (e.g., Raf-MAPK, JNK, WNT, Hippo, Notch, JAK-STAT, and PI3K/AKT) have been implicated in tumor growth and invasion7–10.