To explore whether lineage-primed TFs were affected in HSC/MPP cells from COVID-19 patients, we examined canonical lineage-priming TF modules, including Pre-B-priming TFs (namely PAX5, EBF1, ID3), megakaryocyte progenitor cells (MkP)-priming TFs (namely ETS2, FLI1, GATA2, PBX1), granulocyte progenitor (GP) priming-TFs (namely SPI1, LMO4), and MDP-priming TFs (namely IRF7, IRF8)34–36. The gene discussed is SPI1; the disease is COVID-19.