We present a case of two brothers, from non-consanguineous parents, that physically resemble Carpenter syndrome [MIM:201000], which is a condition characterized by the premature fusion of certain skull bones (craniosynostosis), abnormalities of the fingers and toes, and other developmental problems [4]. Carpenter syndrome can be caused by mutations in the RAB23 or MEGF8 gene and is inherited in an autosomal recessive manner). Here, MEGF8 is linked to Carpenter syndrome.