In line, pathway analysis, using gene set enrichment analysis (GSEA) and the molecular signature database (MSigDB), for which the mouse genes were converted into the human homologs, revealed that the top 25 pathways were dominated by cell cycle, proliferation, EGFR signaling, and tumor progression associated gene signatures, and were expectedly mainly described by the human/tumor derived genes (Additional File 5). Here, EGFR is linked to neoplasm.