Conversely, the other p53 family member, p63 [45–48], although considered a master regulator of pancreatic cancer squamous lineage specification [49, 50] and frequently associated to p53 GOF in other models [51, 52], has not yet emerged with a causative link in driving p53 GOF phenotype of PDAC. Here, TP53 is linked to familial pancreatic carcinoma.