TGFA and familial pancreatic carcinoma: For example, TGFA, a kind of EGFR ligand associated with pancreatic cancer invasion [27] and poor survival (p = 0.0148, log-rank test) (Fig. 3f), was located in an H3K27me3-enriched common contact domain of a primary site but located in an H3K36me3-enriched common contact domain of metastasis with elevated expression (adj.