None of the HIV disease characteristics: nadir CD4 cell count (p = 0.97), time since HIV diagnosis (p = 0.35), diagnosis of AIDS (p = 1.00), ART status (p = 1.00), duration of ART (p = 0.52) and Efavirenz-based ART regimes (p = 0.45) were found to be associated with Global Neurocognitive Impairment. This evidence concerns the gene CD4 and AIDS.