AFP and hepatocellular carcinoma: The ROC curve of single and combined use of the four indicators showed that AFP + Hsp90α was the best combination strategy for the auxiliary diagnosis of HCC, with a sensitivity of 95.7%, a specificity of 97.5%, and an AUC of 0.990 (95% CI, 0.976–1.000) (see Table 6 and Fig. 2).