Cells lacking cGAS or STING show defects in IFN activation in response to the infection of some RNA viruses, including SeV, VSV, IAV and Zika virus.21,22 Unlike DNA virus, RNA virus infection may not lead to quick ubiquitination and phosphorylation of STING, while SeV infection can induce STING expression.23 Although the association between STING with RLRs in RNA virus-mediated immune responses has been indicated, the underlying mechanism remains unclear and awaits for further study. Here, CGAS is linked to infection.