NFKB1 and Hepatic fibrosis: 2016). It mediated hepatotoxicity via decreasing oxidative stress biomarkers (MDA and NO) and increasing GSH concentration. Also, it has anti-inflammatory effects as a reduction in NF-κB activity resulting in a significant increase in NO production (Cichocki et al. 2010). TLRE exhibited anti-inflammatory action may result due to cinnamic acid (408.94 μg/g extract). Itoh et al., 2010 reported that syringic acid and vanillic acid could suppress hepatic fibrosis in CCl4-induced chronic liver injury.