KRAS and colorectal carcinoma: Compared to the other 5 KRAS-mutant CRC cell lines, SW48 and Caco-2 cells, which harbored the wild-type RAS genes, were relatively resistant to RGS, and even when treated with the maximum concentration of RGS (20 μM for 48 h and 1,000 nM for 96 h), the cell viability was greater than 50% (58.6% and 55.4% for 48 h, 65.7% and 70.6% for 96 h, respectively).