Consistent with the results of Ritt et al.12, we found that RGS quickly decreased the p-AKT levels in KRAS-mutant CRC cells after 3 h of incubation, which was consistent with the results reported by Prasad et al.34 and Chapman et al.23 for hematological malignant tumors. This evidence concerns the gene AKT1 and colorectal carcinoma.