PITX2 and cancer: In consideration of the critical role of RGS in regulation of RAS/MEK/ERK and PI3K/AKT signaling in KRAS-mutant cancer cells as reported by Athuluri-Divakar et al.11 and Ritt et al.12, we evaluated the levels of activated pMEK, pERK, and pAKT in DLD1 and HCT116 cells after 0.5–12 h of RGS incubation (Figure 3A).