To sum up briefly, this study was designed to explore how the LPC/G2A axis regulates the expression of ICAM-1 and VCAM-1 in HUVECs and HEK293 cells in which G2A had been knocked down or overexpressed, with the initial aim of investigating the function of G2A in the pathogenesis of atherosclerosis. Here, ICAM1 is linked to atherosclerosis.