After adjusting for age, we found that the group factor (B.1.1.7 variant infection or nonvariant infection) was the main risk factor for higher CRP (odds ratio [OR] = 2.79, P = 0.045), higher SAA (OR = 5.03, P = 0.011), higher CK (OR = 0.22, P = 0.034), GGO (OR = 5.42, P = 0.005), and higher CD4+ T (OR = 3.31, P = 0.029). The gene discussed is CD4; the disease is infection.