Of the nine genes (KLC3, LINC00634, NHLRC4, C11orf45, ZKSCAN2, KIF9, KIF7, SALL1, and ODF3L2) in our signature, researchers have proven that SALL1 can act as a tumor suppressor by recruiting NuRD to induce tumor cell senescence in breast cancer during which it is controlled by the MAPK and mTOR signaling pathways.16 This evidence concerns the gene ZKSCAN2 and neoplasm.