There was also a reduction in antioxidant enzymes, i.e., SOD and catalase (CAT), and thus a decrease in the processing of oxidants, resulting in the production of superoxide anions (O2 ̄), which mediate stimulation activator protein-I (AP-I) and signal transduction processes involved with nuclear factor kappa (NF-kB) [10], leading to cancer. The gene discussed is SOD1; the disease is cancer.