These data indicate that LINC00857 contributes to Scutellarin‐induced c‐Myc downregulation via acting as a miR‐150‐5p sponge and EGR1 promotes anticancer effect of Scutellarin on osteosarcoma cells through regulating LINC00857/miR‐150‐5p/c‐Myc axis. This evidence concerns the gene MYC and osteosarcoma.