The possible mechanism why Netrin-1 and its receptors UNC5b are expressed in atherosclerotic plaque is that atherosclerosis-induced local inflammation causes hypoxia, which in turn mediates transcription factor-1 release, and subsequently, this transcription factor-1 induces the production of Netrin-1 and its receptors UNC5b [48]. The gene discussed is UNC5B; the disease is atherosclerosis.