The main purpose of this 10-year retrospective study was to identify possible biomarkers in glioma comparing some routine coagulation factors such as d-dimer, fibrinogen, Antithrombin III (ATIII), Factor VIII (FVIII), PT, PTT and the ratio of complete blood count components such as NLR and PLR among the following subgroups: a) patients with glioma, patients with MS, and controls; b) patients with non-recurrent and patients with recurrent glioma. The gene discussed is F8; the disease is central nervous system cancer.