In the light of the above literature, the current study aimed to investigate the obesity-associated gene polymorphisms ADIPOQ rs1501299 and rs2241766, and FTO rs1477196, rs7206790, rs8047395 and rs9939609 in Turkish postmenopausal estrogen-receptor (ER) positive (+) BC patients and healthy control individuals in order to determine the links between them. This evidence concerns the gene ESR1 and obesity disorder.