Epicardial fat, similar to other visceral adiposity, acts as an endocrine or paracrine organ and produces proinflammatory adipokines and interleukins such as vaspin, TNF-α, interleukin-6, interleukin-17, and angiotensin (Lana et al., 2016[20]); all of which are involved in the development and progression of cardiovascular and fatty liver disease (Şengül and Özveren, 2013[36]). The gene discussed is TNF; the disease is fatty liver disease.