HK2 and breast cancer: The cell migration (Fig. 7B) and invasion (Fig. 7C) were found to be inhibited in the presence of miR-216b mimic (both p < 0.05), which was negated by overexpression of HK2. These findings demonstrated that miR-216b inhibited the cell proliferation, migration and invasiveness in BC by down-regulating HK2 in BC.