In addition, knockdown of IGF2BP2 reduced the stability and expression level of OIP5-AS1, thereby reducing the combination of OIP5-AS1 and miR-495-3p, enhancing the negative regulation of miR-495-3p on HIF1A and MMP14, and ultimately inhibiting the proliferation, migration, invasion and VM in glioma cells. The gene discussed is OIP5; the disease is glioma.