For example, in non-small cell lung cancer, METTL3 combines with SUMO1 to make SUMO modification of METTL3 regulate its m6A RNA methyltransferase activity, resulting in the decrease of m6A level in mRNAs, and ultimately affect the growth of cell colonies and xenograft tumors 38. The gene discussed is METTL3; the disease is non-small cell lung carcinoma.